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For example, ER stress activates DNA damage inducible transcript 3 (DDIT3, also known as CHOP)- and mitogen-activated protein kinase 8 (MAPK8, also known as JNK)-dependent apoptosis pathways, whereas heat shock protein family A member 5 (HSPA5, also known as BIP) SSG at Cys420/441 modulates ATPase activity and protein folding, paradoxically suppressing apoptosis 49

Bibcode:1981JBact.145..442A

Ovarian cancer derived extracellular vesicles promote the cancer progression and angiogenesis by mediating M2 macrophages polarization

Excessive production of reactive oxygen species over the power of the antioxidant system as oxidative stress is known to contribute to a variety of diseases like PCOS