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[90] reported that stress resulted in an increase in the accumulation of IL-2 in culture supernatant, which was accompanied by a downregulation of IL-2R expression and IL-2R messenger RNA levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Wilkinson PK, Sedman AJ, Sakmar E, Earhart RH, Weidler DJ, Wagner JG

while the binding of GSH to Ts24GST causes a decrease in the number of intramolecular hydrogen bonds, an increase in the radius of gyration and a decrease in its thermal stability

During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)