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To test this, we investigated the vulnerability to ferroptosis of ageing nematodes upon the natural loss of glutathione during lifespan

10.1074/JBC.RA119.008491 77 HolmA.HansenS

& Puga, A

Unlike earlier compounds that affected multiple methyltransferases, 5-amino-1MQ demonstrates remarkable specificity for NNMT without inhibiting related SAM-dependent enzymes or components of the NAD+ salvage pathway