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Mechanistically, HIF-1 binds to hypoxia-response elements (HREs) within the PD-L1 promoter, enhancing its expression in both tumor cells and immunosuppressive myeloid populations such as macrophages and MDSCs, thereby reinforcing an immune-resistant TME [329]

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For example, minoxidil is a topical medication that can help stimulate hair follicles, while finasteride is an oral medication that can block the hormone dihydrotestosterone (DHT), which is associated with male pattern baldness

However, like any medical procedure involving needle insertion and medication delivery, there are risks to consider