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Emerging Treatment Mechanisms for Depression: Focus on Glutamate and Synaptic Plasticity

Zeisel 1 , (1)Cancer Research Center of Lyon (CRCL), Umr Inserm 1052 Cnrs 5286 Mixte Clb, Universit Lyon 1 (UCBL1), (2)Department of Hepatology, Croix Rousse Hospital, Hospices Civils De Lyon, France Background: Enhancer of Zeste Homolog 2 (Ezh2) is frequently upregulated in hepatocellular carcinoma (HCC) tissues and increased Ezh2 expression correlates with HCC aggressiveness and/or poor prognosis

Phase I/II trials for various cancers (NCT04480502, NCT02465285) are evaluating liposomal curcumin in combination with radiotherapy or chemotherapy, with preliminary data indicating enhanced tumor suppression and reduced toxicity [24]

Subsequently, 20 l of buffer containing 10 mM Tris-HCl (pH 7.5), 300 mM sucrose and 1.0 mM EDTA was added to the glass tube, which was then sealed and incubated at 45 C for 8 min (prehydration)