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Dysfunction in these interactions, specifically the overactivation of adenosine A2A receptors, can lead to an imbalance in the basal ganglia circuitry, resulting in abnormal motor function and contributing to the motor symptoms characteristic of PD

In the future, clinical studies on diet and PD need to conduct more large-scale long-term cohort studies and randomized controlled trials to explore the relationship between diet and PD in greater depth and provide more scientific evidence for proposing PD-related diet intervention strategies and preventing and treating PD using nonpharmacological means

doi: 10.1186/s12967-020-02455-0 9 JasonLARichmanJARademakerAWJordanKMPlioplysAVTaylorRRet al