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An investigation utilizing a rodent model of cancer cachexia revealed increased palmitic acid and decreased LA levels in WAT, associated with downregulated expression of ELOVL6, a gene encoding an enzyme crucial for fatty acid elongation

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AKT is a key regulator in the insulin signaling pathway and regulates several downstream proteins, such as the transcription factor FOXO1, glycogen synthase kinase 3 (GSK3) as well as mTOR and Forkhead transcription factors [65, 66]

CD8+ T cells have a crucial role in tumor immunity resulting in part from the release of different cytotoxic molecules (for example, granzyme B, perforin)