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Annu Rev Biochem (2001) 70:81120

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Some pathological abnormalities, such as inflammation of the submucosal glands and hyperplasia of goblet cells, may contribute to chronic sputum production, although these pathological abnormalities are not present in all patients with this symptom

The expression or activity of SLC7A11 is regulated by a variety of factors, such as TP53, 85 NFE2L2, 86 BRCA1-associated protein 1 (BAP1), 87 mucin 1, cell surface-associated (MUC1), 88 or BECN1, 71 which in turn form a complex network to control GSH levels in ferroptosis