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Docking simulation using Glutathione S-transferases A1-1 monomer without Glutathione conjugate was receptor against Glutathione, Ellagic acid, Lycopene, -Tocopherol acetate, Quercetin, Ethacrynic acid, Caffeic acid, Porphyrin, Ferulic acid, Curcumin, Dithiothreitol, Cinnamic acid, Iodoacetamide, -Tocopherol, Beta-mercaptoethanol showed that the majority ligands tested bound at sites bordering the enzyme subunit-subunit interface

Biochem Biophys Res Commun 279:324329 Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG (2004) Genetically altered mice to evaluate glutathione homeostasis in health and disease

The second pathway involves conversion by tryptophan 2,3-dioxygenase (TDO) in the liver and IDO(indoleamine 2,3-dioxygenase 1) in other tissues (brain, gastrointestinal tract, liver) into the kynurenine pathway, where approximately 90% of tryptophan is degraded [184,185,186]

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