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[DOI] [PubMed] [Google Scholar] 90.Zhang Y.H., Zhong J.J., Yu J.T

Innervation from splanchnic afferent extends throughout the entire gastrointestinal tract [4]

This action is likely related to SINs ability to enhance IB protein expression, effectively inhibiting NF-B signaling and regulating micro-glial inflammation (4, 95, 96)

Strategies such as surface modification, hydrogel encapsulation, or scaffold-assisted delivery may improve targeting and therapeutic persistence in the joint cavity (186)