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A 2021 human study published on NCBI found that GI issues were more common with semaglutide 2.4 mg compared to a placebo

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Garg P, Arora U, Kumar A, Wig N

While PGC1 is linked to mitochondrial biogenesis and increased ROS production, it also enhances the expression of detoxifying enzymes, thus controlling the oxidative defense system [36,38,39]