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Population history and its impact on medical genetics in Quebec

Neuroinflammation markers should include: neurofilament light chain (NfL, reflecting axonal injury), glial fibrillary acidic protein (GFAP, reflecting astrocyte activation), and soluble triggering receptor expressed on myeloid cells 2 (sTREM2, reflecting microglial activation) (174, 175)

Their core value lies in synergizing with conventional treatments to enhance efficacy and reduce adverse effects, addressing unmet needs in ADs such as long-term remission maintenance and slowing early disease progression, without replacing core first-line therapies