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doi: 10.3389/fonc.2025.1700439 Received 11 September 2025 Accepted 27 October 2025 Published 17 November 2025 Volume 15 - 2025 Edited by Zodwa Dlamini, Pan African Cancer Research Institute (PACRI), South Africa Reviewed by Yuan Qin, Xijing Hospital, The Air Force Medical University, China Hong Sun, Fudan University, China Updates Copyright 2025 Ao, Liu, Yin and Zhao

( a ) iPSC-derived DA neurons underwent the 14 d dual hit treatment regime and stained with tyrosine hydroxylase antibody (TH, blue) and phospho--syn (pSyn, pS129 antibody) antibody (red)