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Activation of oncogenes leads to tumorigenesis, which controls cell proliferation and apoptosis

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

For intracellular cytokine staining, the murine cells were stimulated for 5 h at 37 C with PMA (500 ng/mL) plus ionomycin (500 ng/mL), in the presence of brefeldin A and monensin