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Menke, Christoph (2021) : Zweite Natur

Based on the microbiome-ENS axis, we therefore provide a summary of the preclinical and clinical data on the role of microbiota in regulating the ENS and improving GI motility

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Figure 2B focuses on direct and incretin-mediated signaling to the -cell, depicting how BefA, LPS and microbial tryptophan metabolites act on intestinal epithelial and enteroendocrine cells to modulate GIP and GLP-1 secretion and how these hormones, together with BefA, engage GIPR/GLP1R, cAMPPKA/EPAC2 and PI3K/AKT pathways to regulate -cell Ca 2+ influx, survival, proliferation and insulin granule exocytosis