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The increased oxidative damage leads to apoptosis

Research indicates a strong connection between particular inflammatory factors, elements related to oxidative stress, and markers like matrix metalloproteinases with both the structural integrity of the membranes and the inflammatory response ( 3.1 Inflammation-related biochemical markers The integrity of the fetal membrane relies on both its mechanical strength and the regulation of local and systemic inflammatory responses ( Lactobacillus and an increase in pathogenic bacteria (e.g., Sneathia spp.) are associated with increased fragility of the fetal membranes and the onset of early neonatal sepsis (EONS) ( 3.1.1 Various inflammatory cytokines Research has shown that the microbiota associated with premature rupture of membranes, including Gardnerella vaginalis and Atopobium vaginae, are significantly linked to increased pro-inflammatory factors ( Table 2 )