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Ouyang et al., 2024)

In various diseases, multiple sites are modified simultaneously [123]

2-[[3-(3-Methoxyphenyl)-1-oxopropyl]amino]-N-(2,4,6-trimethylphenyl)-6-benzothiazolecarboxamide

It is worth noting that many of the top ATF4-dependent genes that scored as being induced by the ISR alone showed some degree of rapamycin-sensitive induction with insulin but did not reach statistical significance in the RNA-seq analyses