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This bidirectionality may explain why some nutrient interventions fail [e.g., vitamin B12 supplementation is ineffective in patients with gut microbiota dysbiosis (149)]

Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase

Treatment with 4mg daily cibinetide for 28 days produced a 23% increase in corneal nerve fiber abundance compared to placebo