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3 At present, the strongest evidence supports sea buckthorn as a bioactive-rich functional food with promising but not yet fully established clinical benefits across all claimed therapeutic domains

Such studies remind us that negative or nuanced outcomes are often the most enlightening, pushing the field forward and helping refine both scientific questions and clinical practice

Foundational work should include translational trials that pair GLP-1RA therapy with deep immunophenotyping (Th1/Th17/Treg balance, inflammasome activity), adipokine profiling (leptin, adiponectin), and gut-barrier/microbiome readouts, alongside thyroid-specific endpoints (Thyroid Peroxidase Antibodies (TPOAb)/Thyroglobulin Antibodies (TgAb)/TRAb trajectories, ultrasound echogenicity and volume, Doppler vascularity, and patient-reported outcomes) [1,3,9,22]