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Another neurological symptom is depression, due to the deficiency leading to higher levels of oxidative stress, DNA damage, and cell death

In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development (Strycharz-Dudziak et al., 2020), obesity (Rusetskaya et al., 2019), signal transduction, and inflammation (Rusetskaya et al., 2019)

When the extracellular potassium concentration increases due to neuronal activity, astrocytes can sense and respond and help maintain the appropriate level of excitatory activity by regulating the distribution of ions

Ham test is confirmatory: When the compliment fixes the RBC at a decreased pH, RBC from the PNH patients lyse, whereas normal RBCs are resistant to lysis