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The observed percent changes in TEMPO-CNFs concentrations in test solutions prepared with ultra-pure water, very soft synthetic water, and blended water were less than 20%, which was used as a guide for dispersion stability in the OECD guidance for nanomaterials and is considered acceptable (OECD 2021)

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In vivo, evidence from animal experiments also supports the role of excess copper in lipid metabolism

406 Mitochondrial dysfunction contributes to cardiac damage, leading to impaired mitophagy, altered enzyme activity in the ETC, and reduced ATP production