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doi:10.1093/toxsci/kfm165

Moreover, inhibition of GS activity in TAMs induces the polarization of M2-type TAMs toward the M1 type, accompanied by a decrease in glutamine levels and increase of succinic acid and accumulation of HIF-1

On the other hand, seborrhea, acne, T2D and cancer are frequently observed in acromegaly with increased GH/IGF-1 signaling in comparison to healthy controls [16]

The discrepancy, discussed above, between the results obtained for the cortex and hippocampus is probably due to the high level of antioxidant enzyme expression in the cortex, which cushions the impact of increased levels of highly oxidizing molecules, thus giving the cortex an advantage over the hippocampus in limiting oxidative stress (Sharma et al., 2013)