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454 In glaucoma mice, mitophagy may also be downregulated, and the mitophagy marker Rheb was observed to be weakened in the retina, 455 so the damaged mitochondria are difficult to be cleared by mitophagy

Chronic pain is a stress to the adrenal glands, though typically not the initial adrenal stressor

High Met diet causes alteration of hepatic prooxidant/antioxidant status and oxidative stress parameters in rats ( Met is directly converted by MATI/MATIII into SAMe, and MATI/MATIII deficiency could lead to decreased SAMe levels and its downstream products including GSH

Conclusion: Combining nasal drug delivery with natural products is a promising strategy for treating CNS, nasal, and chronic diseases, potentially improving clinical efficacy and expanding therapeutic options