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While GLP-1R is known to be expressed in the central nervous system [55], the effectiveness of GLP-1 analogs in patients with MC4R-POMC pathway deficiency has not been well established

Science starts with curiosity and posing a question that is then tested through acquiring data and analyzing the accuracy of that data

Both constructs demonstrated rapid renal clearance and minimal off-target accumulation, validating the multivalent approach as a strategy to restore the in vivo utility of otherwise compromised PSMA-targeting agents [122]