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Furthermore, the role of SLC25A33-mediated mtDNA synthesis and mtROS production in facilitating mtDNA release during macrophage polarization and the dysregulated inflammatory response warrants further investigation

Natural compounds or TCM formulas with ferroptosis-inhibitory effects in other kidney diseases [e.g., berberine and irisflorentin (201, 202)] have not been tested in LN, representing an untapped therapeutic avenue