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Clinical studies are primarily investigating Cagrilintide + GLP-1 agonists (like semaglutide)

Pro-inflammatory cytokine receptors are highly aggregated in regions associated with cognitive functioning such as the hippocam-pus.4546 Pro-inflammatory cytokines and their receptors may inhibit neurogenesis and impair cognitive function.4748 Numerous reports have supported the idea that several pro-inflammatory cytokines affect neurogenesis

Multiple sclerosis and glutamate excitotoxicity

We performed disulfide trapping experiments using the most promising arr1 and Src mutants, based on the results of the arr1SH3 screening (Fig