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Methods Plasmids, adenovirus, antibodies and regents cDNAs for full-length or 1-270aa (NT domain) WT, C45A, K179A, C180A, C371A, D270A, I217N GSDME were synthesized and cloned into pCDNA3.1 vector, and adenovirus-vector-based WT and Cys residues mutant plasmids were all from Sangon Biotech (Shanghai, China)

Future research is needed to further explore the common mechanisms underlying the core symptoms of PTSD to guide the discovery of ideal targets for the treatment of PTSD

doi: 10.3390/ijms262211057 135 SantiDCrpieuxPReiterESpaggiariGBriganteGCasariniLet al

49 Selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants that have been proven to successfully treat clinical depression, were developed in response to this hypothesis, which was derived primarily on the basis of the pharmacological mechanism of drug that were accidentally discovered to act as antidepressants