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10.1046/j.1365-2605.1999.00189.x 118

Other studies further support the beneficial effects of radiotherapy following mastectomy and adjuvant chemotherapy, even in high-risk cases with lymph node involvement, large tumors, compromised surgical margins, or in the presence of multiple risk factors such as age 50 years, triple-negative tumors, high tumor grade, and lymphovascular invasion 52,53