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Insulin signaling and glucose metabolism Insulin exerts a central role in hepatic glucose and lipid homeostasis by modulating insulin receptor substrate (IRS)-mediated signaling

Therefore, DON treatment can not only reduce the self-renewal potential and metastatic ability of pancreatic ductal adenocarcinoma (PDAC) tumor cells but also lead to extensive remodeling of the tumor extracellular matrix (ECM), promoting the infiltration and activation of CD8 + T cells (Sharma et al., 2020)