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When these microbes migrate into the small intestine, they can begin fermenting food, leading to SIBO (small intestinal bacterial overgrowth)

The burst of tiny bubbles in ultrasonic cavitation will produce great pressure, so that the rupture of plant cell wall and the whole organism can be completed in an instant, which shortens the crushing time

That means any damage to the extra-articular side is more likely to heal while the intra-articular side (with a very poor blood supply) does not heal well after injury or surgical repair

Overall, these mechanisms stunt cell proliferation, alter metabolism and gene expression patterns and induce high levels of ROS production, maintaining the cellular senescent phenotype