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60 The mechanism by which Cdkn2a inactivation permits mTORC2 activation in this model is unclear, but may be related to novel roles of Ckdn2a in regulating cellular metabolism

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Tesamorelin elevates IGF-1, and this elevation must remain within normal physiological range (roughly 100 to 300 ng/mL depending on age)

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Glutamate can then be further catalyzed by glutamate dehydrogenase 1 (GDH1) to generate A-ketoglutarate (A-KG), thereby driving glutaminolysis

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