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The population frequency of severe early-onset CBS deficiency ranges from 1 in 60000 to 1 in 900000 between countries, and the worldwide birth frequency of clinically ascertained patients was estimated to be 1:122000 [38]

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on the other hand, NH 2 - substituents undergo acetylation, quaternization, Schiffs base responses, and grafting, in addition to chemical, physical, and enzymatic de-polymerization (Fatullayeva et al., 2022