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Prior results and other individuals results do not guarantee a similar outcome

Cell Death Discovery (2021) 7:113

This shift is associated with reduced cellularity and significant thymus involution[167, 168]

Furthermore, the redox activity of PDI, but not its chaperone function, rescued motor dysfunction and axonopathy in zebrafish models of ALS expressing mutant SOD1, together implying that PDI has an important role both in vitro and in vivo (Parakh et al., 2020)