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Research using cell culture models such as Calu-3 airway epithelial cells, has demonstrated that these cytokines affect the integrity and permeability of pulmonary epithelial barrier integrity by regulating key TJs proteins like occludin, claudin-2, and ZO-1

In addition, the Glu74 and Glu83 residues of ChaC2 are key for directing the conformation of the enzyme and regulating enzyme activity (20)

In this podcast episode, Dr

This effect is attributed to its capacity to restrain the differentiation of CD4+ T cells producing IFN- and IL-17A, alongside reducing the synthesis of correlated cytokines like TNF-, IL-6, IL-17A, and IFN- in splenic cells