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General categories of these cytotoxic payloads include anti-microtubule agents (i.e., DM1) and agents that exert DNA damage such as topoisomerase I inhibitors (i.e., SN-38, deruxtecan) [16]

Interestingly, the same results were not observed in healthy age-matched mice, as 6 weeks of progressive ladder-climbing RT (3 climbs, progression from 50% to 100%MCL, 5 times per week) decreased lipid peroxidation in the cerebral cortex but increased lipid peroxidation in the hippocampus (Schimidt et al., 2019)