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(2010) utilized IGF-1 and its analogs to investigate the relative contributions of PI3K/Akt versus MAPK/ERK signaling in IGF-1R-mediated cellular responses, demonstrating context-dependent pathway utilization across different cell types

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In particular, an increase in ROS generation, a decrease in energy storage, and a loss of mitochondrial membrane potential have been observed [126]

In a separate study in 2023, Hu et al., 2023 demonstrated that CDGSH iron-sulfur domain 2 (CISD2) was upregulated and activated the Nrf2/HO-1 signaling pathway in both the MCAO mouse model and the OGD/R HT22 cell model, mimicking in vivo and ex vivo conditions of cerebral ischemia and reperfusion