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Limitations of Preclinical Studies and Translation Barriers The translational potential of current preclinical evidence for human pulmonary hypertension (HPH) faces significant limitations and hurdles

Inflammatory signaling disrupts insulin action in adipocytes and hepatocytes by impairing key components such as IRS-1, the insulin receptor, and peroxisome proliferator activated receptor gamma (PPAR), thereby exacerbating metabolic dysfunction (53)