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Summary of molecular imaging studies in late-life depression With respect to neurotransmitter deficits in LLD, pre-synaptic serotonergic deficits are observed, especially in cortical and limbic regions, while post-synaptic receptors (5-HT1A, 5-HT2A, 5-HT4) are affected to a limited extent, in contrast to MCI, AD and PD that show more widespread pre and post- synaptic serotonin deficits

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J Control Release 301:6275 Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, Runfeldt M, Shytle RD, Tan J (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces -amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice