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Eight days after tumor cell implantation, mice were randomly distributed in 4 treatment groups of fourteen animals each and administered via oral gavage with daily doses of vehicle, 100 mg/kg/day Palbociclib, 150 mg/kg/day Telaglenastat, or 100 mg/kg/day Palbociclib + 150 mg/kg/day Telaglenastat for 23 consecutive days

Collectively, our results reveal that the Palbociclib and Telaglenastat combined treatment can effectively forestall acquired resistance to Palbociclib and significantly improve the efficacy of either treatment alone in vivo

10.1016/j.chembiol.2019.01.008 174 ZhaoS.HuangM.YanL.ZhangH.ShiC.LiuJ.et al (2022)

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