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Specifically, dihydroartemisinin reduced Fe 2+ levels at an early stage and triggered iron autophagy, resulting in the degradation of iron autophagy-related proteins, FTH1 and NCOA4, followed by an increase in Fe 2+ levels ( 5.2.5 Antimycobacterial effects Artemisia annua , artemisinin, and their derivatives have a bacteriostatic effect on M

Relative bacterial abundance in skin tissue was assessed through quantitative real-time PCR (qPCR) The experimental procedures for intervention, sample collection, and extraction of microbial genomic DNA were performed as Experimental animals with minor modifications

Another in vivo study also demonstrated ultra-structural defects in mitochondria of intestinal cells such as swollen and degenerated mitochondria with disintegrated cristae after 5-FU administration (Gawish et al