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However, administration of much larger doses of cancer chemotherapy agents in rats, such as paclitaxel either as a single bolus (12.532 mg/kg) (Authier et al., 2007) or as cumulative doses (8 and 16 mg/kg once-weekly for 5 weeks) (Cavaletti et al., 1995) or bortezomib at 2.44.8 mg/kg (Cavaletti et al., 2007

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The researchers found that the rates of subclinical atherosclerosis progression, as measured by changes in common carotid artery intima-media thickness or coronary artery calcium, did not differ significantly between men assigned to the testosterone or placebo groups