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37,38 These agents have serotonergic and noradrenergic activity, as well as -opioid binding, so they have some effect on descending antinociceptive central pathways

doi: 10.1016/S0196-9781(99)00025-X 135 AsarianLGearyN

The future likely involves both drugs coexisting as options for different patient profiles, similar to how semaglutide and tirzepatide both have their place in current practice