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Declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Zhengzhou University Peoples Hospital

Strict & absolute sun protection against UVB, UVA & HEV blue light is the foundation of treatment

Circulation 137 , 13741390 (2018)

Wrinkle reduction Yes Regeneration and healing Yes Antioxidant effects Yes Improved skin elasticity Yes Safety of use Yes Scientific data and sources Research summary Level of evidence Preliminary Number of included studies: 20 8 studies 5 studies 4 studies 1 study 1 study 1 study Final comment: Although systematic literature analyses and results from in vitro and animal model studies indicate the effectiveness of GHK-Cu in skin regeneration and wrinkle reduction, there are no direct randomized controlled trials in humans