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In turn, the receptor phosphorylation promotes STATs phosphorylation and dissociation from the GHR as well as the dimerization and translocation to the nucleus, where it activates specific transcription elements on DNA and regulates the transcription of different genes, including IGF-1 ( Figure 1 )

Ann Intern Med 158(1):19 Lavonas EJ, Drennan IR, Gabrielli A, Heffner AC, Hoyte CO, Orkin AM, Sawyer KN, Donnino MW (2015) Part 10: special circumstances of resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care

Amino acids, transporters, and metabolites participate in tumor immunity through metabolic reprogramming