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Regions flanking the core motifs and post-translational modifications, such as phosphorylation, can play a crucial role in modulating binding specificity and affinity 1720

antibodies of the invention bind antigenic epitope-bearing peptides and polypeptides of EphA2, and said antigenic epitope-bearing peptides and polypeptides comprise or consist of an amino acid sequence of at least 4, at least 5, at least 6, at least 7, more preferably at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50 continguous amino acid residues, and, preferably, between about 15 to about 30 continguous amino acids of EphA2 found in any species

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Instead, they reduce electron loss from the ETC, which is one of the main sources of mitochondrial ROS formation