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Selection based on preliminary experiments For example, when the researchers selected the dose to be administered for SRS16-86, five groups were modeled as sham group, SCI group, SCI + 5 mg/kg SRS16-86 group, SCI + 10 mg/kg SRS16-86 group and SCI + 15 mg/kg SRS16-86 group, and then tested motor recovery 2 weeks after SCI to select a dose of 15 mg/kg SRS16-86 (Zhang Y

These results underscore the critical importance of selecting appropriate experimental models, as differences in experimental models could result in entirely opposite conclusions

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Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders