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ACSL4 (acyl-CoA synthetase long-chain family member 4) is a key positive regulator of ferroptosis that catalyzes the esterification of long-chain polyunsaturated fatty acids (such as arachidonic acid), converting them into acyl-CoA derivatives and thereby facilitating the synthesis of polyunsaturated phospholipids that are highly susceptible to lipid peroxidation

Without adequate blood supply, fracture healing fails

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