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This represents an important step in the right direction for developing innovative treatments for patients with an incredibly high unmet medical need

Peer review Peer review information Nature Communications thanks Xiuting Li, Weibin Liang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Why is DsbA such an oxidizing disulfide catalyst

There is also concern about TCAs causing possible cardiotoxicity, therefore, caution should be used in patients with known or suspected cardiac disease [28],[40]