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The following applies: Even though overdoses rarely have critical consequences, you should always use high doses with caution and have your blood levels checked regularly if you are unsure

Strikingly, we found acinar cells were replaced by SOX2 + cells in the IR SLG (GFP + cells) similar to the nonIR control with the production of both SOX2 + GFP + and SOX2negative progeny (Fig 5D, white arrowheads indicate SOX2negative progeny), suggestive of the presence of a transitamplifying cell which is no longer SOX2 + but derived from a SOX2 + cell (i.e., lineagetraced)

doi:10.1038/s41430-021-00875-9 Mansuri NM, Mann NK, Rizwan S, et al

If jaundice and/or marked liver enzyme elevations (eg, 5 times the upper limit of normal) develop, ZYMFENTRA should be discontinued and a thorough investigation of the abnormality should be undertaken