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(ii) iron-catalyzed auto-oxidation, and (iii) oxidase- and esterase-mediated peroxidation of polyunsaturated fatty acids (PUFA) (Yang and Stockwell, 2016

VFMC, VG, JT, CS, HE, YYB, CB, MZ, ART and FG designed experiments

For the third cohort receiving 6 mg/kg DCR-PHXC, the mean maximal 24-h Uox reduction reached 76% (range: 58100%)

Advantage : CagriSema Dosing Convenience# CagriSema : Once-weekly subcutaneous injection of fixed-dose combination (2.4 mg cagrilintide + 2.4 mg semaglutide)